Current Understanding of the Etiology, Symptomatology, and Treatment Options in Premature Ovarian Insufficiency (POI)

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نارسایی تخمدان به‌دنبال درمان سرطان و روش‌های حفظ باروری

Primary ovarian insufficiency (POI), commonly referred to premature ovarian failure, is defined as ovarian failure before the age of 40 years. It is the loss of ovarian function caused by a process directly affecting ovaries. Cancer therapy which includes surgery, radiotherapy, and chemotherapy influence ovarian function, leading to premature menopause and loss of fertility. POI is idiopathic i...

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Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unkno...

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Primary ovarian insufficiency or premature ovarian failure (POI/POF) is one the causes of female infertility. POI is defined as cessation of menstrual periods, increased levels of FSH and diminished levels of estrogens before the age of 40. POI occurs in about 1% of women between 30 to 40 years of age, 0.1% of those under 30 and 0.01% of women under the age of 20. Fertility of women with POI is...

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ژورنال

عنوان ژورنال: Frontiers in Endocrinology

سال: 2021

ISSN: 1664-2392

DOI: 10.3389/fendo.2021.626924